Journal article
Cyclin D1 splice variants: Polymorphism, risk, and isoform-specific regulation in prostate cancer
CES Comstock, MA Augello, R Pe Benito, J Karch, TH Tran, FE Utama, EA Tindall, Y Wang, CJ Burd, EM Groh, HN Hoang, GG Giles, G Severi, VM Hayes, BE Henderson, L Le Marchand, LN Kolonel, CA Haiman, R Baffa, LG Gomella Show all
Clinical Cancer Research | Published : 2009
Abstract
Purpose: Alternative CCND1 splicing results in cyclin D1b, which has specialized, protumorigenic functions in prostate not shared by the cyclin D1a (full length) isoform. Here, the frequency, tumor relevance, and mechanisms controlling cyclin D1b were challenged. Experimental Design: First, relative expression of both cyclin D1 isoforms was determined in prostate adenocarcinomas. Second, relevance of the androgen axis was determined. Third, minigenes were created to interrogate the role of the G/A870 polymorphism (within the splice site), and findings were validated in primary tissue. Fourth, the effect of G/A870 on cancer risk was assessed in two large case-control studies. Results: Cyclin ..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
American Chemical Society grant IRG114958 (C.E.S. Comstock), NIH grant CA099996 (K.E. Knudsen), National Health and Medical Research Council grant 276408 (R.L. Sutherland), Cancer Institute New South Wales, Australian Cancer Research Foundation, and FIT Hall Trust. The Risk Factors for Prostate Cancer Study was supported by the National Health and Medical Research Council, Australia (209057, 251533, and 450104); VicHealth; The Cancer Council Victoria; The Whitten Foundation; and Tattersall's. The Multiethnic Cohort Study was supported by the National Cancer Institute grants CA63464 and CA54281 and Department of Health and Human Services contracts N01-PC-35139 and N01-PC-35137). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.